A post-doctoral position is available in the lab of Bojana Gligorijevic in Philadelphia, US.
Intravital Microscopy of Cancer Cells Plasticity & Phenotypic Switching in Metastasis
The project aims to investigate the extracellular biology of tumor microenvironment, including interactions between cancer cells with surrounding extracellular matrix and its metabolites. In addition, we are interested in the role of such interactions in the cancer cell switching between behaviors such as proliferation, motility, dormancy and apoptosis. Our aim is to identify and investigate interactions predictive of future dissemination and metastasis. Towards this goal, we use state-of-art intravital multiphoton microscopy technologies, many of which we developed in the lab. These are integrated with classical molecular and cell biology, controllable engineered microenvironments and systems approaches.
Gligorijevic lab is at Temple University BioEngineering Department and member lab of Cancer Biology Program Fox Chase Cancer Center. Temple BioE is a young, inspiring department founded in 2012, focused on mechanobiology and biomechanics in health and disease. Fox Chase Cancer Center is founding member of the network of NCI designated Comprehensive Cancer Centers, listed as the best Cancer Hospital in US numerous times. Fox Chase labs were awarded two Nobel Prizes. Related to our projects, SCID mouse strain and the concepts of Beatrize Mintz which we now call tumor microenvironment we both developed at Fox Chase Cancer Center.
The successful candidate will have a PhD in Life Science and is expected to have a strong background in one or more: microscopy and image processing, cell motility, mouse models of cancer, cancer biology, quantitative/systems view. Funding is available for 3 years; candidates are expected to pursue independence.
天普大学(Temple University，又作坦普尔大学)位于美国东岸宾夕法尼亚州的费城。天普大学是一所综合性的大学，学生人数大约三万四千人。分布大学内十七所学院，包括商学院、法学院、医学院、药剂学院、牙医学院。天普大学是宾夕法尼亚州内三所公立大学之一。另外两所分别是匹茨堡大学与宾夕法尼亚州州立大学。以大学占地规模计算，天普大学在全美是面积第28大的高等教育机构，拥有134个本科专业，121个硕士专业以及56个博士专业。天普大学是一所公立综合性研究型大学，一直致力于贯彻平等教育的理念。在全美近4000所大学中，天普大学拥有雄厚的专业实力:11 个专业排名全美前十名，四个专业排名全美前 20 名，数十个专业排名全美前一百名。美国公立大学排名第60位。